Multiple CT‐X antigens (e.g., MAGEA, CT1; GAGE, CT4; NY‐ESO‐1, CT6; PAGE, CT16; and TSPY1, CT78) are highly expressed in prostate cancer accompanied by DNA demethylation, and changes in DNA methylation status are associated with tumor metastasis.14 This evidence concerns the gene TSPY1 and prostate carcinoma.