(3) Hyperhomocysteinemia is closely associated with the cardiometabolic disorder (e.g. higher LDL‐C, SBP and lower APOA1),9, 10, 11 which indicates that the impacts of rs1801133 on SBP, LDL‐C, APOA1 and hs‐CRP levels in male patients with CAD are possibly mediated by hyperhomocysteinemia. Here, APOA1 is linked to hyperhomocysteinemia.