Since cardiometabolic disorder12, 13, 14, 15 was related to the risk of CAD, it indicated that the impact of rs1801133 on CAD in male patients (Table 1) was mediated by the impacts of rs1801133 on homocysteine, SBP, LDL‐C, hs‐CRP and APOA1 (Table 2). The gene discussed is APOA1; the disease is coronary artery disorder.