Previous studies have shown that PTEN, a tumor suppressor antagonizing PI3K/Akt signal transduction and inactivating 50% of GBMs, leads to uncontrolled PI3K/Akt signaling in GBM (Knobbe and Reifenberger, 2003; Jhanwar-Uniyal et al., 2022). This evidence concerns the gene AKT1 and neoplasm.