SCN8A and epilepsy: We selected amitriptyline (AMI), carvedilol (CVD), and nilvadipine for testing in the Scn8aR1620L/+ (RL/+) mouse line based on a previous in vitro screen that suggested these drugs might be efficacious in SCN8A-derived epilepsy due to their ability to inhibit sodium influx (Atkin et al., 2018).