SCN8A and autism: In the current study, we evaluated the ability of amitriptyline, carvedilol, nilvadipine, and fenfluramine to increase resistance to induced seizures in CF1 wild-type (WT) mice and in mice expressing the human SCN8A R1620L mutation which was identified in a patient with behavioral seizures, ADHD, autism, and social behavior challenges (Rossi et al., 2017).