GPR88 and Dyskinesia: Similarly, in a Gpr88-inactivated lentiviral-mediated knock-down striatal 6-OHDA rat model, a specifically designated microRNA (miR) (KD-Gpr88) reduced acute amphetamine-induced turning behavior and normalized striatal Gad67 and proenkephalin expression, indicating to an association with the severity of L-DOPA induced dyskinesia (Ingallinesi et al., 2019).