GPR52 is predominantly expressed in the brain, particularly in regions associated with symptoms of neuropsychiatric disorders and Huntington’s disease (Komatsu et al., 2014; Nishiyama et al., 2017; Hatzipantelis et al., 2020a; Wang P. et al., 2020; Ma et al., 2020). Here, GPR52 is linked to juvenile Huntington disease.