NAFLD is also associated with the activity of nitric oxide synthase (NOS), and inducible NOS (INOS), two endogenous molecules often associated with liver pathological consequences, among which the promotion of lipid peroxidation and mitochondrial damage, the inhibition of hepatocyte protein synthesis and glucose homeostasis, all events which accelerate hepatocyte death. Here, NOS2 is linked to metabolic dysfunction-associated steatotic liver disease.