APP and Alzheimer disease: We demonstrated the ability of a Gd-DOTA-ob5- cyanine5.5 (cy5.5) contrast agent to detect oAβ using fluorescence imaging in cell experiments, and ex-vivo and in-vivo experiments using APP/PS/ApoE knockdown (KD) AD mouse model, also known as 3xTg AD mice (Kim et al., 2023).