Additionally, the ongoing increase in the contrast effect in 3xTG AD over time and the decrease in APP/PS/Tau AD suggest a difference in the amount of oligomeric amyloid-β circulating around the amyloid plaques, indicating a more dominant formation of amyloid plaques in 3xTG AD compared to APP/PS/Tau AD Hence, our contrast agent proposes the flexibility in evaluating differences due to amyloid oligomers, suggesting its translational potential across model species. Here, APP is linked to Alzheimer disease.