HMOX1 and colitis: But on the other hand, research by CHEN et al. found that Astragalus polysaccharides (APS) could prevent murine colitis and ferroptosis in human Caco-2 cells by inhibiting this signaling pathway.It suggested that ferroptosis may be regulated through the Nrf2/HO-1 signaling pathway in DSS-induced UC (Chen et al., 2020).