AGT and triple-A syndrome: However, the three main AAA models currently available are elastase, CaCl2, and angiotensin II (AngII)/apolipoprotein E (AapoE)-deficient mouse models, each of which has defects that may not translate the findings to human AAA, and there is currently insufficient evidence from multiple clinical drug trials to conclusively prove the complete efficacy of these drugs in treatment (11, 12).