Zhang et al. previously identified upregulation of the lncRNA plasmacytoma variant translocation 1 (PVT1) in human AAA tissue and AngII induced murine AAA; lentiviral knockdown of PVT1 in an AngII murine model attenuated aortic expansion and suppressed VSMC apoptosis, matrix degradation, and inflammatory cytokine profile (108). This evidence concerns the gene PVT1 and triple-A syndrome.