Zhang et al. previously identified upregulation of the lncRNA plasmacytoma variant translocation 1 (PVT1) in human AAA tissue and AngII induced murine AAA; lentiviral knockdown of PVT1 in an AngII murine model attenuated aortic expansion and suppressed VSMC apoptosis, matrix degradation, and inflammatory cytokine profile (108). Here, AGT is linked to triple-A syndrome.