For example, when tau pathology from a human AD patient is injected into a mouse, the structure of tangle aggregates in the mice mirrors that of the patient Clavaguera et al. (2013); furthermore, comorbid Aβ/tau mouse models can reproduce Braak staging of tauopathy in the absence of a seed Hurtado et al. (2010). This evidence concerns the gene MAPT and tauopathy.