While we lacked sufficient data to explore whether Aβ influences directionality in mouse tauopathy models, the fact that primary tauopathies (such as frontolobartemporal dementia, FTLD) and secondary tauopathies (such as AD) exhibit different etiologies suggests that Aβ may influence how tau spreads on the network. The gene discussed is MAPT; the disease is tauopathy.