Using the multi-cancer optimization approach, ENPP1 and CDH11, validated novel targets by Mooney and colleagues, scored in the top 2% of targets (Fig. 4A) and using the phenotype-specific prioritization parameters, IL1RAP, a previously validated target within EwS, ENPP1 and CDH11 scored as the top three targets (Fig. 4B) (Supplemental Tables S4–S5). This evidence concerns the gene IL1RAP and cancer.