Using the multi-cancer optimization approach, ENPP1 and CDH11, validated novel targets by Mooney and colleagues, scored in the top 2% of targets (Fig. 4A) and using the phenotype-specific prioritization parameters, IL1RAP, a previously validated target within EwS, ENPP1 and CDH11 scored as the top three targets (Fig. 4B) (Supplemental Tables S4–S5). Here, CDH11 is linked to cancer.