IL6 and Cowden syndrome 1: IVW analysis revealed that beta‐nerve growth factor (β‐NGF) (OR = 1.0026; 95% CI: 1.0026–1.0047; p = 0.01223; Padjust = 0.0983), C‐X‐C motif chemokine 6 (CXCL6) (OR = 1.0012; 95% CI: 1.0004–1.0021; p = 0.0041; Padjust = 0.0327), and interleukin‐6 (IL‐6) (OR = 1.0021; 95% CI: 1.0003–1.0038; p = 0.0244; Padjust = 0.1950) can increase the risk of CS (Figure S2).