Prostate cancer-upregulated long noncoding RNA1 (PLnc RNA1), a newly discovered lncRNA transcript, also known as CBR3 antisense RNA 1 (CBR3-AS1), located on chromosome 21q22.12, is upregulated in hepatocellular carcinoma (34), esophageal squamous cell carcinoma (35) and prostate cancer (Figure 2) (36). The gene discussed is CBR3-AS1; the disease is Familial prostate cancer.