C3 and IgA glomerulonephritis: Danicopan (NCT05162066), iptacopan (NCT04817618, NCT05755386) and Pegcetacoplan (NCT04729062) targeting Factor D, Factor B, and C3 respectively, have shown promise in PNH but are being trialed for diseases like C3 glomerulopathy and IgA nephropathy.