A greater number of genes are upregulated in DCs after MRV infection, many of which are involved in the innate immune response (i.e. Ifit1, Ifit3, Mx1, Gbp2, Oasl1, Isg15, Ccr1, Ifitm2, Oaxl2, Casp1, Casp4) that would be predicted in response to a viral infection (Figure 7A). This evidence concerns the gene ISG15 and viral infectious disease.