IRS1 and infection: At 24 hours post-infection, C002 (Δγ134.5, IRS1, mIL-12) produced significantly greater infectious virus than did M002 (1.19x107 PFU/ml vs. 1.5x106 PFU/ml, p=0.008) or the control Δγ134.5 oHSV (1.19x107 PFU/ml vs. 4.9x105 PFU/ml, p=0.0064).