CD4(+) T cells expressing IL-17 and IL-21 constituted less than 0.89 ± 0.11% of all cytokine-producing CD4(+) T cells, indicating minimal involvement of Th17 and T- follicular helper (Tfh) in the tumor microenvironment (Supplementary Figures 5O, P). This evidence concerns the gene IL21 and neoplasm.