According to our data, both CRD mice and Bmal1-/- mice exhibited more severe intestinal barrier dysfunction in the presence of DSS-induced colitis, which may be mediated by decreased TJ proteins (Claudin-1, Occludin and ZO-1) expression and increased apoptosis of IECs, thus aggravated the severity of colitis. The gene discussed is TJP1; the disease is colitis.