Besides inhibiting LPL, ANGPTL3 inhibits endothelial lipase (EL).58 In a recent paper, we showed that the LPL-independent effects of ANGPTL3 inactivation on plasma metabolic parameters showed a striking inverse resemblance with EL inactivation, suggesting that ANGPTL3 modulates plasma lipid levels by inhibiting LPL and EL.42 Here, using MR, we compared the effects of genetically instrumented EL and LPL activity on CAD. The gene discussed is LPL; the disease is coronary artery disorder.