ANGPTL3 and atherosclerosis: Dewey et al.3 and Stitziel et al.47 found that rare loss-of-function ANGPTL3 variants were associated with decreased odds of ASCVD, whereas MR studies of common ANGPTL3-lowering variants reported negative findings.46 By meta-analysis of loss-of-function variant genetic association studies, we found clear, statistically robust evidence that lifetime genetic inactivation of ANGPTL3 confers protection against CAD.