ANGPTL4 and Lymphadenopathy: The mechanism behind the fatal chylous lymphadenopathy observed in mice was purportedly the loss of inhibition of LPL in macrophages, which caused them to take up excess lipids, leading to massive inflammation in the mesenteric lymph system.14 Exposure to ANGPTL4 inactivation was instrumented using two different models: by the ANGPTL4 p.E40 K coding variant, and by the ANGPTL4 p.Cys80frameshift (fs) variant.