ANGPTL4 and coronary artery disorder: ANGPTL4 protein-truncating variant carrier status was also associated with a reduced risk of CAD (meta-analysis IVW OR: 0.31 per TG, P = 0.045), as was APOC3 protein-truncating variant carriers status (meta-analysis IVW OR: 0.73 per TG, P = 0.004).