ANGPTL3 targets both EL and LPL and may thus influence CAD via two independent pathways.49 To compare the effects of these two target enzymes, we analysed the effects of genetically instrumented EL and LPL activity on CAD by performing functional-variant limited MR of the LIPG (encoding EL) and LPL genes. The gene discussed is LIPG; the disease is coronary artery disorder.