While certain Treg phenotypes, such as CD28+ CD45RA+ CD8br %CD8br and Activated & resting Treg %CD4+, exhibit neuroprotective effects, others like CD127 on granulocyte, CD3 on CD39+ secreting Treg, CD4 on activated & secreting Treg, DN (CD4-CD8-) AC are associated with an elevated risk of stroke. The gene discussed is ENTPD1; the disease is Stroke.