This type of tumor has marked nuclear atypia, microvascular proliferation or necrosis, high cellular density, and high mitotic activity, or at least one of the following characteristics: Telomerase reverse transcriptase (TERT) promoter mutation, epidermal growth factor receptor (EGFR) amplification, or concomitant gain of chromosome 7 and loss of chromosome 10 [9,11]. This evidence concerns the gene EGFR and neoplasm.