Since the mutation in CDKN2A is recognizable in this cell cycle process as a result of cell cycle arrest through the p53 pathway, for that reason, CDKN2A is a suppressive gene in colon adenocarcinoma (COAD) by investigating gene deletion mutations in chromosome 9p21, which is related to most adenocarcinoma tumors [2]. Here, CDKN2A is linked to colon adenocarcinoma.