LEP and preeclampsia: Furthermore, to gain a deeper understanding of the significance of the five candidate genes in placental immunomodulation in preeclampsia, correlation analysis revealed that ANKRD37 is negatively correlated with CD56dim.natural.killer.cell, CRH is negatively correlated with Type.2.T.helper.cell, LEP is negatively correlated with Effector.memory.CD8.T.cell, and SIGLEC6 is positively correlated with Type.1.T.helper.cell (Figure 7B).