According to Yu et al. (2020), three children with relapsed ALL had four acquired relapse-specific mutations in FPGS. Unexpectedly, Schroeder et al. (2019) and Li et al. (2020) identified a new relapse-specific mutation in the FPGS gene that solely affected B-ALL and exhibited relapse-specific lesions and stable losses. The gene discussed is FPGS; the disease is acute lymphoblastic leukemia.