Ding et al. (2017) later performed WES and TS in 11 trios of B-ALL patients with diagnoses, full remissions, and relapses. They found the RTK-Ras signaling pathway, epigenetic regulators, transcriptional factors, and p53/cell cycle pathway were the most significantly mutated genes throughout the entire cohort (Ding et al., 2017). The gene discussed is TP53; the disease is acute lymphoblastic leukemia.