TP53 and colorectal cancer: Colorectal cancer has the highest occurrence of p53 mutations, with 53% in all colon cancer samples and approximately 70% in recurrent samples (Gao et al., 2022), resulting in the loss of tumor-suppressing function, which endows tumor cells with an advantage by preventing intrinsic tumor suppressive responses such as senescence and apoptosis in response to chemotherapy (Hu et al., 2021).