A more recent study found that ghrelin inhibited GSIS in islets from non-T2D and T2D donors and that ghrelin mRNA expression and fasting circulating ghrelin levels were lower in T2D patients.172 The findings from this study further support ghrelin’s ability to mediate insulinostatic actions, and that reduction in plasma ghrelin could either promote T2D pathogenesis or be an adaptive response to stop further reduction in insulin secretion in T2D patients. Here, GHRL is linked to type 2 diabetes mellitus.