ADIPOQ and hyperlipidemia: Interestingly, adiponectin inhibits lipolysis in adipocytes giving it insulin-like effects on adipocytes, so during fasting and a subsequent decrease in adiposity, the actions of this hormone prevent lipolysis.89 This seems counterproductive as during the fasting state adipocytes need to release stored fat and it is likely glucagon action promotes net lipolysis in adipocytes- perhaps adiponectin reduces the rate of lipolysis to stop hyperlipidaemia.