GIPR and type 2 diabetes mellitus: Interestingly, GIP has been shown to stimulate glucagon secretion even with high glucose in T2D patients, which implies that inappropriate GIP/GIPR activity contributes to the T2D disease phenotype.313 It has been shown that fatty acids strongly enhance GIP secretion, and this hormone then subsequently plays an important role in mediating fat uptake into adipose tissue.314,315