Hypoglycaemia results in the sympathetic and parasympathetic nervous systems mediating glucagon secretion from islet alpha-cells.113 The nervous system also inhibits glucagon secretion indirectly through the insulin secretion that it induces during the fed state.60 When blood glucose concentration rises, this then raises the intracellular ATP/ADP ratio in islet alpha-cells. Here, GCG is linked to Hypoglycemia.