This includes reduced sFC between Hb and visual cortex in MDD patients compared to controls (Zhu et al., 2023), greater sFC between Hb and precuneus in TRD compared to controls (Barreiros et al., 2022), and a study which found increased sFC between contralateral NAc and cerebellum in adolescent MDD patients compared to controls (Chen et al., 2023). The gene discussed is GSTM1; the disease is treatment resistant depression.