AKT1 and hepatocellular carcinoma: A few years later, enhancement of HO-1 expression in a human hepatocellular carcinoma cell line (HepG2 cells) by eckol from brown algae Ecklonia stolonifera, mediated by activation of the Nrf2 signaling pathway through c-Jun N-terminal kinases (JNK) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), supported the possibility of using this phlorotannin as a natural antioxidant and cytoprotector.51