Subsequently, we conducted the CRISPR screening in three types of stem cell senescence models, including replicative senescent hMSCs (RS hMSCs) (Fig. S1D and S1E), Werner syndrome (WS, WRN-deficient) hMSCs (Fig. S1F and S1G), and Hutchinson-Gilford progeria syndrome (HGPS, carrying the heterozygous LMNAG608G/+ mutation) hMSCs (Fig. S1H and S1I). This evidence concerns the gene WRN and Hutchinson-Gilford progeria syndrome.