Recent studies have also shown that the METTL1/WDR4 complex can enhance the translation of cell cycle genes (such as CCNA2, CCND2, CDK6, and CDK8) and oncogenes (such as EGFR, EFEMP1, and KDM1A), leading to the development of gliomas, pancreatic cancer, liver cancer, lung cancer, BC, and other tumors.[15, 16, 17, 18, 19] Thus, METTL1/WDR4‐mediated tRNA m7G modification plays a key role in tumor development. The gene discussed is WDR4; the disease is central nervous system cancer.