CD36 is a key molecule that leads to signal transduction of intracellular fatty acid storage, modulating intracellular fatty acid homeostasis and the pathological process of NAFLD.[23, 56, 57] Rubicon has been confirmed to participate in the lipid metabolic progress in adipocytes by regulating the adipogenic genes including CD36, indicating a strong association between Rubicon and adipogenesis.[18] Our preliminary analysis of data from NAFLD patients illustrated a positive relationship between Rubicon and CD36. Here, CD36 is linked to metabolic dysfunction-associated steatotic liver disease.