LMNA and Hutchinson-Gilford progeria syndrome: The alternative splicing products of the lamin A/C (LMNA) gene, lamin A and lamin C, are major components of the nuclear skeleton.[1] Mature lamin A is produced by posttranslational processing of the initial translation product prelamin A.[2] Mutations in the LMNA gene are closely related to Hutchinson–Gilford progeria syndrome (HGPS).