In previous studies, the suppressive effect of E2F4 on most FA/BRCA genes has been established.[32] However, the promoting effect of E2F1 on FA/BRCA genes has only been validated in a limited number of genes.[16a] Therefore, we aimed to provide a comprehensive analysis of the regulatory role of E2F1 in a broader spectrum of genes within the FA/BRCA pathway. The gene discussed is E2F1; the disease is Friedreich ataxia.