BMPR2 is a serine-threonine kinase receptor of transforming growth factor (TGF)-β superfamily that signals to inhibit cell growth and studies with genetic siRNA knockdown of BMPR2 in human PAH endothelial cells demonstrate higher levels of glycolysis; healthy human endothelial cells transfected with mutant BMPR2 have greater glycolysis and increased expression of glycolytic mediator biosynthetic pathways [48,49]. The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.