VEGFA and hemorrhoid: Ceylan Dönmez et al., through animal studies [56], have shown that extracts from eggplant (Solanum melongena L.)possess significant anti-inflammatory and hemorrhoid improvement activities, as they can reduce levels of the inflammatory cytokine TNF-α, decrease levels of vascular endothelial growth factor (VEGF), which is highly correlated with hemorrhoid [57], and reduce capillary permeability.