Additionally, in a HepG2 cell model induced with palmitic acid/oleic acid (PA/OA) to mimic NASH conditions, Kae demonstrated the capacity to decrease lipid droplet accumulation and downregulate the expression of NLRP3-ASC/TMS1-Caspase 3 (20 μM and the final concentration to 20 nM). This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.