Several studies in the literature reported on the different biological activities of B-type proanthocyanidins like anti-cancer activity by decreasing the in vitro growth of androgen-sensitive (LnCaP) and androgen-resistant (DU145) human prostate cancer cell lines [52], antimicrobial activity against Candida albicans and Cryptococcus neoformans, with MIC values of 250 to 1000 μg/mL [53], and anti-aging activity by reducing the content of ROS and nicotinamide adenine dinucleotide phosphate oxidases 4 (NOX4) mRNA levels in luteinized granulosa cells (hGC) and tumor granulosa cells (KGN) [54]. This evidence concerns the gene NOX4 and neoplasm.