As the changes in Aβ42 levels and plaque load were paralleled by significant increases in SOD activity and by post-translational oxidative protein nitration in the hippocampus of zeolite-treated animals, and by reduced mitochondrial ROS production and accumulation in vitro, the authors attributed the beneficial AD effects in the mice to the zeolite antioxidant effects. Here, SOD1 is linked to Alzheimer disease.