Non-physiological increases in Fe in brain regions of AD patients (including the hippocampus, substantia nigra, globus pallidum, putamen, and caudate nucleus) [148] along with robust evidence for a role of Fe in Aβ aggregation and toxicity, for its enrichment in senile plaques and NFTs and for furthering AD pathology (including accelerating the aggregation of tau proteins), have been reported [149,150,151,152]. The gene discussed is MAPT; the disease is Alzheimer disease.