MAPT and Alzheimer disease: Moreover, although neurodegenerative diseases are typically defined by specific protein aggregates (assemblies) (such as amyloid-β (Aβ) plaques and hyperphosphorylated tau protein aggregates as in AD, TDP-43 as in LATE and ALS, and α-synuclein as in PD and Lewy body disorders), they share many common fundamental features linked to progressive neuronal dysfunction and death such as oxidative stress, programmed cell death, and neuroinflammation [1,5,6].