The pro-health properties of Yerba Mate, widely described in the literature may contribute to the prevention of diseases such as obesity [8], insulin resistance, or diabetes [9], e.g., by reducing body weight and the amount of food consumed, increasing the rate of gastric emptying, lowering insulin level, and improving glucose and lipid metabolism (closely related to adipose tissue), as well as increasing the concentration of glucagon-like peptide 1 (GLP-1) and leptin, factors responsible for the feeling of satiety [8,9]. Here, GCG is linked to Insulin resistance.