Besides, baicalein can inactivate the G protein-coupled estrogen receptor (GPR30) signaling pathway and decrease the phosphorylation of AKT and ERK 1/2, the tyrosine phosphorylation of AKT and ERK 1/2, and the tyrosine phosphorylation of epidermal growth factor receptor (EGFR) in breast cancer cells, leading to the suppression of the migration and invasion of cancer [52]. This evidence concerns the gene AKT1 and breast cancer.