At least two pon2 single-nucleotide polymorphisms (SNPs), corresponding to A148G and S311C, have been reported to be associated with decreased lactonase activity and alterations in plasma lipid levels in patients affected by human diseases related to oxidative stress such as coronary artery disease (CAD) [13,14,15], type 2 diabetes mellitus, Alzheimer’s disease [16,17], cataracts [18], and COVID-19 [19]. The gene discussed is PON2; the disease is type 2 diabetes mellitus.