Although the B7-H3 protein is known to be expressed in activated dendritic cells, monocytes, T cells, B cells, natural killer (NK) cells, tumor-infiltrating lymphocytes (TILs), and tumor-associated macrophages (TAMs), which affect tumor growth, metastasis, and drug resistance [5,9], its immunological functions remain unclear as it affects T-cell activation and inhibition as well as NK cell responses. This evidence concerns the gene CD276 and neoplasm.