Moreover, the proliferation was considerably reduced in the different CRISPR-Cas9 IGF1R-knockout clones (Figures S4 and S5) of both the L-363 (IGF1Rmut) and U-266 (IGF1RWT) cells (Figure 1A,B), confirming the role of IGF1R as an important survival and proliferation factor in MM. The gene discussed is IGF1R; the disease is Miyoshi myopathy.