In addition, the latter considers a favorable intermediate-risk class to be a subset defined by PSA levels between 10–20 ng/mL or tumor grade group 2, according to the International Society of Urologic Pathology (ISUP) system, or clinical stage cT2b-2c and a less than 50% percentage of biopsy positive cores (BPC); nevertheless, patients may present with PSA < 10 ng/mL as well ISUP grade group 2, thus representing a very favorable subgroup, but are still included in the aforementioned group [1,2]. Here, KLK3 is linked to neoplasm.