So far, early PCa may encompass highly favorable subsets within the low- and intermediate-risk categories defined by the EAU, including patients with PSA levels < 10 ng/mL, BPC < 50%, and non-palpable tumors (cT1c), but differing only in the ISUP grade group, which is 1 for the former and 2 for the latter, respectively. Here, KLK3 is linked to posterior cortical atrophy.