KLK3 and neoplasm: Our results showed that adverse tumor grade was an independent negative prognostic factor in a highly selected population, including EAU low- and intermediate-risk classes, which closely resembled each other, in including PSA < 10 ng/mL, clinical stage cT1c, BPC < 50%, but differed only in biopsy ISUP, defined as 1 for the former and 2 for the latter.