EGFR and non-small cell lung carcinoma: The phase III FLAURA trial assessed osimertinib vs. standard EGFR TKI in NSCLC and reported 22% of patients with new brain lesions on osimertinib vs. 41% on standard EGFR TKI, and 5% of patients progressed to develop BM on osimertinib vs. 12% in the control arm [46].