BCL2 and high grade B-cell lymphoma: Moreover, dysregulated BCL2 is a hallmark of more aggressive subsets of DLBCL, such as those that have both BCL2 and MYC rearrangements (originally called double-hit DLBCL), now classified as DLBCL high-grade B-cell lymphoma (HGBL), which are typically GCB subtype [18].