However, elevated BCL2 and BAK levels and reduced BCLW levels were a shared feature among intrinsically venetoclax-sensitive DLBCL lines, which was the opposite in the intrinsically venetoclax-resistant lines, suggesting a reciprocal relationship of these proteins and a potential for using them as biomarkers of venetoclax sensitivity/resistance. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.