This occurs in many cancer-related genes, some of them being driver genes themselves, such as Caspase 8 (CASP8), Tumor Protein P53 (TP53), MDM4 Regulator Of P53 (MDM4), BRCA1 DNA Repair-Associated (BRCA1), and Dicer 1 Ribonuclease III (DICER1) [64]. Here, CASP8 is linked to cancer.