IDH2 and central nervous system neoplasm: The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) proposed a diagnostic entity for Grade 2 and 3 isocitrate dehydrogenase (IDH)-wildtype astrocytoma, which resembles GB due to TERTp mutation, EGFR amplification, or a combination of whole chromosome 7 gain and 10 loss (+7/−10) [40].