Unlike MPDCP, in which pDCs are mature, pDCs in pDC-AML are characterized by a full spectrum of maturation composed of various stages of pDCs, including the early forms expressing CD34 and CD117 with low levels of CD4 and CD303 and the late/mature forms that are completely negative for CD34 and CD117 expression with high expression of CD4 and CD303 [8]. Here, CD4 is linked to acute myeloid leukemia.