CD28 and T-cell non-Hodgkin lymphoma: As for T-cell lymphomas, genetic studies have shown the correlation with reference antigens, specifically CD279/PD1, CD10, BCL6, CXCL13, ICOS, SAP, and CCR5, but also genetic abnormalities included TET2, IDH2, DNMT3A, RHOA, and CD28 mutations, or gene fusions (for example ITK-SYK or CTLA4-CD28) [65].