ERBB2 and metastatic neoplasm: Among 12 cases with multiple blocks examined: 5 involved primary EC surgical specimens and subsequent biopsies of recurrent or metastatic disease; 4 included testing of both primary EC and synchronous regional metastasis; 1 had a diagnostic pre-surgical biopsy and local recurrence biopsy tested; 1 had a pre-surgical biopsy, primary resection, and metastatic tumor tested; and 1 involved a primary EC specimen and subsequent metastatic pleural effusion tested for HER2 (Table 2).